Symbol
Name
ID

Foxn1
forkhead box N1
MGI:102949

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased helper T cell proportion	T lymphocytopenia
Disease(s) Associated with FOXN1	Decreased helper T cell proportion	T lymphocytopenia
T-cell immunodeficiency, congenital alopecia, and nail dystrophy

Mouse Phenotypes

increased thymocyte apoptosis

abnormal thymus morphology

abnormal thymus development

abnormal thymus epithelium morphology

absent thymus cortex

abnormal thymus corticomedullary boundary morphology

abnormal thymus medulla morphology

absent thymus medulla

thymus hyperplasia

small thymus

thymus atrophy

thymus hypoplasia

athymia

decreased thymocyte number

increased DN1 thymic pro-T cell number

thymus cyst

abnormal thymus involution

abnormal T cell differentiation

decreased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

increased eosinophil cell number

increased neutrophil cell number

increased granulocyte number

abnormal leukocyte cell number

abnormal lymphocyte cell number

increased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

increased T cell number

decreased lymphocyte cell number

decreased leukocyte cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal spleen morphology

small spleen

spleen hypoplasia

abnormal splenic cell ratio

decreased immunoglobulin level

abnormal T cell activation

Availability

Mouse Genotype

Foxn1^nu-2J/Foxn1^nu-2J

Foxn1^nu-StL/Foxn1^nu-StL

Foxn1^nu-str/Foxn1^nu-str

Foxn1^nu-Y/Foxn1^nu-Y

Foxn1^nu/Foxn1^nu
Tg(Foxn1)E1Hon/0

Foxn1^nu/Foxn1^nu

Foxn1^sepe/Foxn1^sepe

Foxn1^{tm1.1(KOMP)Vlcg}/Foxn1^{tm1.1(KOMP)Vlcg}

Foxn1^tm1.1Cbln/Foxn1^tm1.1Cbln

Foxn1^tm1Dmsu/Foxn1^tm1Dmsu

Foxn1^tm1Nrm/Foxn1^tm1Nrm

Foxn1^tm1Tbo/Foxn1^tm1Tbo

Foxn1^nu-StL/Foxn1^tm1Tbo

Foxn1^nu/Foxn1⁺

Foxn1^tm1.1Cbln/Foxn1⁺

Foxn1^tm1.1Cbln/Foxn1^tm1Tbo

Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0 (conditional)

Foxn1^tm2Tbo/Foxn1^tm2Tbo
Tg(KRT14-cre/ERT2)1Ipc/0 (conditional)

Foxn1^nu/Foxn1^tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺
Foxn1^tm3(cre)Nrm/Foxn1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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